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Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial

BACKGROUND: Air way intubation for general anesthesia usually leads to sore throat after surgery. Ketamine plays an important role to block a number of receptors related to pain. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug that has been used to improve oropharyngeal disorders...

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Autores principales: Faiz, Seyed Hamid Reza, Rahimzadeh, Poupak, Poornajafian, Alireza, Nikzad, Naghme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219213/
https://www.ncbi.nlm.nih.gov/pubmed/25371873
http://dx.doi.org/10.4103/2277-9175.143292
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author Faiz, Seyed Hamid Reza
Rahimzadeh, Poupak
Poornajafian, Alireza
Nikzad, Naghme
author_facet Faiz, Seyed Hamid Reza
Rahimzadeh, Poupak
Poornajafian, Alireza
Nikzad, Naghme
author_sort Faiz, Seyed Hamid Reza
collection PubMed
description BACKGROUND: Air way intubation for general anesthesia usually leads to sore throat after surgery. Ketamine plays an important role to block a number of receptors related to pain. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug that has been used to improve oropharyngeal disorders. In this study, it was intended to compare the effect of gargling different solutions before the surgery on post-operative sore throat (POST) in patients who underwent general anesthesia for hysterectomy. MATERIALS AND METHODS: A total of 60 patients who underwent the elective hysterectomy were entered to the randomized controlled trial regarding to the eligibility criteria. Patients were simply randomly allocated to three groups and received one code. Every code was representative for a specific drug: 20 cc normal saline (control group) or 1.5 mg benzydamine in 20 cc solution or 20 mg ketamine in 20 cc solutions. All the research teams were blinded to the received solutions. POST was evaluated with numerical rating scale. The data were entered to SPSS software and analysis of variance (ANOVA) and Kruskal-Wallis one-way analysis of variance test, were performed. RESULTS: The mean ages of ketamine, benzydamine, and normal saline recipients were not significantly different. The trend of the severity of sore throat during the first 24 h after the operation in ketamine recipients was significantly lower than the other two groups (P < 0.001). CONCLUSION: The pain scale after surgery was reduced by using both ketamine and benzydamine, but the ketamine effect was more noticeable.
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spelling pubmed-42192132014-11-04 Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial Faiz, Seyed Hamid Reza Rahimzadeh, Poupak Poornajafian, Alireza Nikzad, Naghme Adv Biomed Res Original Article BACKGROUND: Air way intubation for general anesthesia usually leads to sore throat after surgery. Ketamine plays an important role to block a number of receptors related to pain. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug that has been used to improve oropharyngeal disorders. In this study, it was intended to compare the effect of gargling different solutions before the surgery on post-operative sore throat (POST) in patients who underwent general anesthesia for hysterectomy. MATERIALS AND METHODS: A total of 60 patients who underwent the elective hysterectomy were entered to the randomized controlled trial regarding to the eligibility criteria. Patients were simply randomly allocated to three groups and received one code. Every code was representative for a specific drug: 20 cc normal saline (control group) or 1.5 mg benzydamine in 20 cc solution or 20 mg ketamine in 20 cc solutions. All the research teams were blinded to the received solutions. POST was evaluated with numerical rating scale. The data were entered to SPSS software and analysis of variance (ANOVA) and Kruskal-Wallis one-way analysis of variance test, were performed. RESULTS: The mean ages of ketamine, benzydamine, and normal saline recipients were not significantly different. The trend of the severity of sore throat during the first 24 h after the operation in ketamine recipients was significantly lower than the other two groups (P < 0.001). CONCLUSION: The pain scale after surgery was reduced by using both ketamine and benzydamine, but the ketamine effect was more noticeable. Medknow Publications & Media Pvt Ltd 2014-10-21 /pmc/articles/PMC4219213/ /pubmed/25371873 http://dx.doi.org/10.4103/2277-9175.143292 Text en Copyright: © 2014 Faiz. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Faiz, Seyed Hamid Reza
Rahimzadeh, Poupak
Poornajafian, Alireza
Nikzad, Naghme
Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title_full Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title_fullStr Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title_full_unstemmed Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title_short Comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: A randomized controlled trial
title_sort comparing the effect of ketamine and benzydamine gargling with placebo on post-operative sore throat: a randomized controlled trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219213/
https://www.ncbi.nlm.nih.gov/pubmed/25371873
http://dx.doi.org/10.4103/2277-9175.143292
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