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Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice

BACKGROUND: Cyperus rotundus L. was used in traditional Iranian medicine to treat memory and cognition disorders. The present study was aimed at investigating the effect of the extract and essential oil of C. rotundus on memory dysfunction. MATERIALS AND METHODS: Cognition was evaluated using the ob...

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Autores principales: Rabbani, Mohammed, Ghannadi, Alireza, Malekian, Nahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219216/
https://www.ncbi.nlm.nih.gov/pubmed/25371874
http://dx.doi.org/10.4103/2277-9175.143293
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author Rabbani, Mohammed
Ghannadi, Alireza
Malekian, Nahid
author_facet Rabbani, Mohammed
Ghannadi, Alireza
Malekian, Nahid
author_sort Rabbani, Mohammed
collection PubMed
description BACKGROUND: Cyperus rotundus L. was used in traditional Iranian medicine to treat memory and cognition disorders. The present study was aimed at investigating the effect of the extract and essential oil of C. rotundus on memory dysfunction. MATERIALS AND METHODS: Cognition was evaluated using the object recognition task that was composed of a square wooden open field box with different shape objects. The test was consisted of three sections: 15 min exploration, first trial for 12 min and second one for 5 min. In the second trial the difference in exploration between a previously seen object and novel one, was considered as an index of memory performance (recognition index). Memory deficit was induced by scopolamine (0.5 mg/kg) before injection of plant extracts and essential oil. RESULTS: Rivastigmine at 0.6 mg/kg reversed the scopolamine induced memory dysfunction in mice (P < 0.05). On the contrary, neither the hydroalcholic extracts (100, 200, 400 mg/kg) nor the polyphenolic extract (50, 100, 200 mg/kg) and essential oil (10, 20, 40 mg/kg) of C. rotundus produced significant improvement of memory dysfunction. The fact that rivastigmine reversed the scopolamine-induced memory dysfunction confirms the validity of this memory paradigm. CONCLUSION: Using the current method of the memory evaluation, none of the tested doses of the plant extract or essential oil changed the memory status of the animals, indicating either a lack of effective ingredient or unsuitable method for evaluation.
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spelling pubmed-42192162014-11-04 Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice Rabbani, Mohammed Ghannadi, Alireza Malekian, Nahid Adv Biomed Res Original Article BACKGROUND: Cyperus rotundus L. was used in traditional Iranian medicine to treat memory and cognition disorders. The present study was aimed at investigating the effect of the extract and essential oil of C. rotundus on memory dysfunction. MATERIALS AND METHODS: Cognition was evaluated using the object recognition task that was composed of a square wooden open field box with different shape objects. The test was consisted of three sections: 15 min exploration, first trial for 12 min and second one for 5 min. In the second trial the difference in exploration between a previously seen object and novel one, was considered as an index of memory performance (recognition index). Memory deficit was induced by scopolamine (0.5 mg/kg) before injection of plant extracts and essential oil. RESULTS: Rivastigmine at 0.6 mg/kg reversed the scopolamine induced memory dysfunction in mice (P < 0.05). On the contrary, neither the hydroalcholic extracts (100, 200, 400 mg/kg) nor the polyphenolic extract (50, 100, 200 mg/kg) and essential oil (10, 20, 40 mg/kg) of C. rotundus produced significant improvement of memory dysfunction. The fact that rivastigmine reversed the scopolamine-induced memory dysfunction confirms the validity of this memory paradigm. CONCLUSION: Using the current method of the memory evaluation, none of the tested doses of the plant extract or essential oil changed the memory status of the animals, indicating either a lack of effective ingredient or unsuitable method for evaluation. Medknow Publications & Media Pvt Ltd 2014-10-21 /pmc/articles/PMC4219216/ /pubmed/25371874 http://dx.doi.org/10.4103/2277-9175.143293 Text en Copyright: © 2014 Rabbani. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Rabbani, Mohammed
Ghannadi, Alireza
Malekian, Nahid
Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title_full Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title_fullStr Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title_full_unstemmed Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title_short Evaluation of the effect of Cyperus rotundus L. in scopolamine-induced learning deficit in mice
title_sort evaluation of the effect of cyperus rotundus l. in scopolamine-induced learning deficit in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219216/
https://www.ncbi.nlm.nih.gov/pubmed/25371874
http://dx.doi.org/10.4103/2277-9175.143293
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