Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders

Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental...

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Autores principales: Boules, Mona M, Fredrickson, Paul, Muehlmann, Amber M, Richelson, Elliott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219245/
https://www.ncbi.nlm.nih.gov/pubmed/25379273
http://dx.doi.org/10.3390/bs4020125
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author Boules, Mona M
Fredrickson, Paul
Muehlmann, Amber M
Richelson, Elliott
author_facet Boules, Mona M
Fredrickson, Paul
Muehlmann, Amber M
Richelson, Elliott
author_sort Boules, Mona M
collection PubMed
description Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.
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spelling pubmed-42192452014-11-06 Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders Boules, Mona M Fredrickson, Paul Muehlmann, Amber M Richelson, Elliott Behav Sci (Basel) Review Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders. MDPI 2014-06-13 /pmc/articles/PMC4219245/ /pubmed/25379273 http://dx.doi.org/10.3390/bs4020125 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Boules, Mona M
Fredrickson, Paul
Muehlmann, Amber M
Richelson, Elliott
Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title_full Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title_fullStr Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title_full_unstemmed Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title_short Elucidating the Role of Neurotensin in the Pathophysiology and Management of Major Mental Disorders
title_sort elucidating the role of neurotensin in the pathophysiology and management of major mental disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219245/
https://www.ncbi.nlm.nih.gov/pubmed/25379273
http://dx.doi.org/10.3390/bs4020125
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