Depletion of STAT5 blocks TEL–SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice

The spleen tyrosine kinase (SYK) was identified as an oncogenic driver in a broad spectrum of hematologic malignancies. The in vivo comparison of three SYK containing oncogenes, SYK(wt), TEL–SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a general myeloexpansion and the establishment of thr...

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Detalles Bibliográficos
Autores principales: Sprissler, C, Belenki, D, Maurer, H, Aumann, K, Pfeifer, D, Klein, C, Müller, T A, Kissel, S, Hülsdünker, J, Alexandrovski, J, Brummer, T, Jumaa, H, Duyster, J, Dierks, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219468/
https://www.ncbi.nlm.nih.gov/pubmed/25148222
http://dx.doi.org/10.1038/bcj.2014.53

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