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Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder
The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case–control cohort. Genotyping of five genome-wide significant...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219535/ https://www.ncbi.nlm.nih.gov/pubmed/25304227 http://dx.doi.org/10.1097/YPG.0000000000000060 |
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author | Witt, Stephanie H. Kleindienst, Nikolaus Frank, Josef Treutlein, Jens Mühleisen, Thomas Degenhardt, Franziska Jungkunz, Martin Krumm, Bertram Cichon, Sven Tadic, André Dahmen, Norbert Schwarze, Cornelia E. Schott, Björn Dietl, Lydia Nöthen, Markus M. Mobascher, Arian Lieb, Klaus Roepke, Stefan Rujescu, Dan Rietschel, Marcella Schmahl, Christian Bohus, Martin |
author_facet | Witt, Stephanie H. Kleindienst, Nikolaus Frank, Josef Treutlein, Jens Mühleisen, Thomas Degenhardt, Franziska Jungkunz, Martin Krumm, Bertram Cichon, Sven Tadic, André Dahmen, Norbert Schwarze, Cornelia E. Schott, Björn Dietl, Lydia Nöthen, Markus M. Mobascher, Arian Lieb, Klaus Roepke, Stefan Rujescu, Dan Rietschel, Marcella Schmahl, Christian Bohus, Martin |
author_sort | Witt, Stephanie H. |
collection | PubMed |
description | The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case–control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Sex-specific analysis showed that this signal was present only in women. This is the first report of an association between a BD risk gene and BPD where selection was not based on a priori hypotheses about its function, but on an unbiased hypothesis-free screening of the genome. Genome-wide association data of large samples of BPD are warranted and will eventually identify new risk genes and the overlap between BPD and BD if it exists. |
format | Online Article Text |
id | pubmed-4219535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-42195352014-11-04 Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder Witt, Stephanie H. Kleindienst, Nikolaus Frank, Josef Treutlein, Jens Mühleisen, Thomas Degenhardt, Franziska Jungkunz, Martin Krumm, Bertram Cichon, Sven Tadic, André Dahmen, Norbert Schwarze, Cornelia E. Schott, Björn Dietl, Lydia Nöthen, Markus M. Mobascher, Arian Lieb, Klaus Roepke, Stefan Rujescu, Dan Rietschel, Marcella Schmahl, Christian Bohus, Martin Psychiatr Genet Brief Reports The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case–control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Sex-specific analysis showed that this signal was present only in women. This is the first report of an association between a BD risk gene and BPD where selection was not based on a priori hypotheses about its function, but on an unbiased hypothesis-free screening of the genome. Genome-wide association data of large samples of BPD are warranted and will eventually identify new risk genes and the overlap between BPD and BD if it exists. Lippincott Williams & Wilkins 2014-12 2014-10-31 /pmc/articles/PMC4219535/ /pubmed/25304227 http://dx.doi.org/10.1097/YPG.0000000000000060 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/3.0. |
spellingShingle | Brief Reports Witt, Stephanie H. Kleindienst, Nikolaus Frank, Josef Treutlein, Jens Mühleisen, Thomas Degenhardt, Franziska Jungkunz, Martin Krumm, Bertram Cichon, Sven Tadic, André Dahmen, Norbert Schwarze, Cornelia E. Schott, Björn Dietl, Lydia Nöthen, Markus M. Mobascher, Arian Lieb, Klaus Roepke, Stefan Rujescu, Dan Rietschel, Marcella Schmahl, Christian Bohus, Martin Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title | Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title_full | Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title_fullStr | Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title_full_unstemmed | Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title_short | Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
title_sort | analysis of genome-wide significant bipolar disorder genes in borderline personality disorder |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219535/ https://www.ncbi.nlm.nih.gov/pubmed/25304227 http://dx.doi.org/10.1097/YPG.0000000000000060 |
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