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C-terminal in Sp1-like artificial zinc-finger proteins plays crucial roles in determining their DNA binding affinity
BACKGROUND: It is well known that the C-terminal zinc-finger-3 in transcription factor Sp1 contributes more than the N-terminal zinc-finger-1 in determining Sp1’s DNA binding capacity. Sp1-like artificial poly-zinc-finger proteins (ZFPs) are powerful biotechnological tools for gene-specific recogniz...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219604/ https://www.ncbi.nlm.nih.gov/pubmed/24289163 http://dx.doi.org/10.1186/1472-6750-13-106 |