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Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder
PURPOSE: Previous work has demonstrated the relatively high prevalence of risk factors for cognitive impairment, such as sleep disordered breathing (SDB) and obesity, in Vietnam War era veterans with post-traumatic stress disorder (PTSD). No data are currently available on the longitudinal stability...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219637/ https://www.ncbi.nlm.nih.gov/pubmed/25378962 http://dx.doi.org/10.2147/NSS.S65034 |
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author | Yesavage, Jerome A Kinoshita, Lisa M Noda, Art Lazzeroni, Laura C Fairchild, Jennifer Kaci Friedman, Leah Sekhon, Gundeep Thompson, Stephanie Cheng, Jauhtai Zeitzer, Jamie M |
author_facet | Yesavage, Jerome A Kinoshita, Lisa M Noda, Art Lazzeroni, Laura C Fairchild, Jennifer Kaci Friedman, Leah Sekhon, Gundeep Thompson, Stephanie Cheng, Jauhtai Zeitzer, Jamie M |
author_sort | Yesavage, Jerome A |
collection | PubMed |
description | PURPOSE: Previous work has demonstrated the relatively high prevalence of risk factors for cognitive impairment, such as sleep disordered breathing (SDB) and obesity, in Vietnam War era veterans with post-traumatic stress disorder (PTSD). No data are currently available on the longitudinal stability of SDB as a risk factor for cognitive decline in that population, which this study now reports. METHODS: Sample consisted of 48 veterans of the Vietnam War with PTSD who completed longitudinal sleep assessments over a 3-year period. The primary outcome measure, the Apnea-Hypopnea Index (AHI) indicator, was determined during standard overnight polysomnography. Body mass index (BMI) was calculated using standard measurements. Measures of cognitive function tapped auditory verbal memory as measured by the Rey Auditory Verbal Learning Test and executive functioning as measured by the Color-Word Interference Test of the Delis–Kaplan Executive Function System battery. Statistical analyses included mixed effects modeling. RESULTS: In this sample, AHI increased significantly by 2.19 points per year (β=2.19; P<0.005). AHI worsened over the 3-year period, increasing from a mean of 18.7±15.7 to 24.7±17.4 points. Neither BMI nor cognition showed significant change over the 3-year period. CONCLUSION: SDB worsened in a group of veterans of the Vietnam War with PTSD over a 3-year period. The worsening of SDB over time suggests the need for appropriate countermeasures in populations at risk for progression of the condition. |
format | Online Article Text |
id | pubmed-4219637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-42196372014-11-06 Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder Yesavage, Jerome A Kinoshita, Lisa M Noda, Art Lazzeroni, Laura C Fairchild, Jennifer Kaci Friedman, Leah Sekhon, Gundeep Thompson, Stephanie Cheng, Jauhtai Zeitzer, Jamie M Nat Sci Sleep Original Research PURPOSE: Previous work has demonstrated the relatively high prevalence of risk factors for cognitive impairment, such as sleep disordered breathing (SDB) and obesity, in Vietnam War era veterans with post-traumatic stress disorder (PTSD). No data are currently available on the longitudinal stability of SDB as a risk factor for cognitive decline in that population, which this study now reports. METHODS: Sample consisted of 48 veterans of the Vietnam War with PTSD who completed longitudinal sleep assessments over a 3-year period. The primary outcome measure, the Apnea-Hypopnea Index (AHI) indicator, was determined during standard overnight polysomnography. Body mass index (BMI) was calculated using standard measurements. Measures of cognitive function tapped auditory verbal memory as measured by the Rey Auditory Verbal Learning Test and executive functioning as measured by the Color-Word Interference Test of the Delis–Kaplan Executive Function System battery. Statistical analyses included mixed effects modeling. RESULTS: In this sample, AHI increased significantly by 2.19 points per year (β=2.19; P<0.005). AHI worsened over the 3-year period, increasing from a mean of 18.7±15.7 to 24.7±17.4 points. Neither BMI nor cognition showed significant change over the 3-year period. CONCLUSION: SDB worsened in a group of veterans of the Vietnam War with PTSD over a 3-year period. The worsening of SDB over time suggests the need for appropriate countermeasures in populations at risk for progression of the condition. Dove Medical Press 2014-10-29 /pmc/articles/PMC4219637/ /pubmed/25378962 http://dx.doi.org/10.2147/NSS.S65034 Text en © 2014 Yesavage et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yesavage, Jerome A Kinoshita, Lisa M Noda, Art Lazzeroni, Laura C Fairchild, Jennifer Kaci Friedman, Leah Sekhon, Gundeep Thompson, Stephanie Cheng, Jauhtai Zeitzer, Jamie M Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title | Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title_full | Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title_fullStr | Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title_full_unstemmed | Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title_short | Longitudinal assessment of sleep disordered breathing in Vietnam veterans with post-traumatic stress disorder |
title_sort | longitudinal assessment of sleep disordered breathing in vietnam veterans with post-traumatic stress disorder |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219637/ https://www.ncbi.nlm.nih.gov/pubmed/25378962 http://dx.doi.org/10.2147/NSS.S65034 |
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