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Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohort-Based Modeling Study

BACKGROUND: Elevated risk of HIV-1 infection among recipients of an adenovirus serotype 5 (Ad5)-vectored HIV-1 vaccine was previously reported in the Step HIV-1 vaccine efficacy trial. We assessed pre-infection cellular immune responses measured at 4 weeks after the second vaccination to determine t...

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Detalles Bibliográficos
Autores principales:	Huang, Yunda, Duerr, Ann, Frahm, Nicole, Zhang, Lily, Moodie, Zoe, De Rosa, Steve, McElrath, M. Juliana, Gilbert, Peter B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219669/ https://www.ncbi.nlm.nih.gov/pubmed/25369172 http://dx.doi.org/10.1371/journal.pone.0108631

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