Cargando…

Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival

BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP). METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical...

Descripción completa

Detalles Bibliográficos
Autores principales: Jensen, David Hebbelstrup, Hedback, Nora, Specht, Lena, Høgdall, Estrid, Andersen, Elo, Therkildsen, Marianne Hamilton, Friis-Hansen, Lennart, Norrild, Bodil, von Buchwald, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219682/
https://www.ncbi.nlm.nih.gov/pubmed/25369118
http://dx.doi.org/10.1371/journal.pone.0110456
_version_ 1782342618308411392
author Jensen, David Hebbelstrup
Hedback, Nora
Specht, Lena
Høgdall, Estrid
Andersen, Elo
Therkildsen, Marianne Hamilton
Friis-Hansen, Lennart
Norrild, Bodil
von Buchwald, Christian
author_facet Jensen, David Hebbelstrup
Hedback, Nora
Specht, Lena
Høgdall, Estrid
Andersen, Elo
Therkildsen, Marianne Hamilton
Friis-Hansen, Lennart
Norrild, Bodil
von Buchwald, Christian
author_sort Jensen, David Hebbelstrup
collection PubMed
description BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP). METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records. RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038–0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis. CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up.
format Online
Article
Text
id pubmed-4219682
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-42196822014-11-12 Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival Jensen, David Hebbelstrup Hedback, Nora Specht, Lena Høgdall, Estrid Andersen, Elo Therkildsen, Marianne Hamilton Friis-Hansen, Lennart Norrild, Bodil von Buchwald, Christian PLoS One Research Article BACKGROUND: The purpose of this study was to examine the prevalence of human papillomavirus (HPV) in patients with head and neck squamous cell carcinoma of unknown primary (CUP). METHODS: All patients diagnosed with and treated for CUP between January 1, 2000, and June 1, 2011, at two Danish medical centers were included. All patients received a thorough diagnostic work-up, including FDG-PET, before being diagnosed as CUP. We determined the HPV status in all patients using a combination of HPV DNA PCR and p16 stain. In addition, clinical information on the study patients was retrieved from clinical records. RESULTS: Of the identified 60 patients with CUP, 13 were shown to be positive for HPV DNA, amounting to 22% of the study population. In addition, we were able to show a clear disease-free and overall-survival benefit in the HPV-positive group, with a hazard ratio of 0.16 (95% CI: 0.038–0.67) for over-all survival. This survival benefit was also apparent when adjusted for advanced age in a multivariate Cox regression analysis. CONCLUSION: A fairly large percentage of CUP cases are HPV-related, and because this is related to both the location and prognosis, we recommend HPV testing as part of the diagnostic work-up. Public Library of Science 2014-11-04 /pmc/articles/PMC4219682/ /pubmed/25369118 http://dx.doi.org/10.1371/journal.pone.0110456 Text en © 2014 Jensen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jensen, David Hebbelstrup
Hedback, Nora
Specht, Lena
Høgdall, Estrid
Andersen, Elo
Therkildsen, Marianne Hamilton
Friis-Hansen, Lennart
Norrild, Bodil
von Buchwald, Christian
Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title_full Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title_fullStr Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title_full_unstemmed Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title_short Human Papillomavirus in Head and Neck Squamous Cell Carcinoma of Unknown Primary Is a Common Event and a Strong Predictor of Survival
title_sort human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219682/
https://www.ncbi.nlm.nih.gov/pubmed/25369118
http://dx.doi.org/10.1371/journal.pone.0110456
work_keys_str_mv AT jensendavidhebbelstrup humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT hedbacknora humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT spechtlena humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT høgdallestrid humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT andersenelo humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT therkildsenmariannehamilton humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT friishansenlennart humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT norrildbodil humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival
AT vonbuchwaldchristian humanpapillomavirusinheadandnecksquamouscellcarcinomaofunknownprimaryisacommoneventandastrongpredictorofsurvival