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Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging
Yttrium-90 is known to have a low positron emission decay of 32 ppm that may allow for personalized dosimetry of liver cancer therapy with (90)Y labeled microspheres. The aim of this work was to image and quantify (90)Y so that accurate predictions of the absorbed dose can be made. The measurements...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219690/ https://www.ncbi.nlm.nih.gov/pubmed/25369020 http://dx.doi.org/10.1371/journal.pone.0110401 |
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author | Attarwala, Ali Asgar Molina-Duran, Flavia Büsing, Karen-Anett Schönberg, Stefan O. Bailey, Dale L. Willowson, Kathy Glatting, Gerhard |
author_facet | Attarwala, Ali Asgar Molina-Duran, Flavia Büsing, Karen-Anett Schönberg, Stefan O. Bailey, Dale L. Willowson, Kathy Glatting, Gerhard |
author_sort | Attarwala, Ali Asgar |
collection | PubMed |
description | Yttrium-90 is known to have a low positron emission decay of 32 ppm that may allow for personalized dosimetry of liver cancer therapy with (90)Y labeled microspheres. The aim of this work was to image and quantify (90)Y so that accurate predictions of the absorbed dose can be made. The measurements were performed within the QUEST study (University of Sydney, and Sirtex Medical, Australia). A NEMA IEC body phantom containing 6 fillable spheres (10–37 mm ∅) was used to measure the (90)Y distribution with a Biograph mCT PET/CT (Siemens, Erlangen, Germany) with time-of-flight (TOF) acquisition. A sphere to background ratio of 8∶1, with a total (90)Y activity of 3 GBq was used. Measurements were performed for one week (0, 3, 5 and 7 d). he acquisition protocol consisted of 30 min-2 bed positions and 120 min-single bed position. mages were reconstructed with 3D ordered subset expectation maximization (OSEM) and point spread function (PSF) for iteration numbers of 1–12 with 21 (TOF) and 24 (non-TOF) subsets and CT based attenuation and scatter correction. Convergence of algorithms and activity recovery was assessed based on regions-of-interest (ROI) analysis of the background (100 voxels), spheres (4 voxels) and the central low density insert (25 voxels). For the largest sphere, the recovery coefficient (RC) values for the 30 min –2-bed position, 30 min-single bed and 120 min-single bed were 1.12±0.20, 1.14±0.13, 0.97±0.07 respectively. For the smaller diameter spheres, the PSF algorithm with TOF and single bed acquisition provided a comparatively better activity recovery. Quantification of Y-90 using Biograph mCT PET/CT is possible with a reasonable accuracy, the limitations being the size of the lesion and the activity concentration present. At this stage, based on our study, it seems advantageous to use different protocols depending on the size of the lesion. |
format | Online Article Text |
id | pubmed-4219690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42196902014-11-12 Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging Attarwala, Ali Asgar Molina-Duran, Flavia Büsing, Karen-Anett Schönberg, Stefan O. Bailey, Dale L. Willowson, Kathy Glatting, Gerhard PLoS One Research Article Yttrium-90 is known to have a low positron emission decay of 32 ppm that may allow for personalized dosimetry of liver cancer therapy with (90)Y labeled microspheres. The aim of this work was to image and quantify (90)Y so that accurate predictions of the absorbed dose can be made. The measurements were performed within the QUEST study (University of Sydney, and Sirtex Medical, Australia). A NEMA IEC body phantom containing 6 fillable spheres (10–37 mm ∅) was used to measure the (90)Y distribution with a Biograph mCT PET/CT (Siemens, Erlangen, Germany) with time-of-flight (TOF) acquisition. A sphere to background ratio of 8∶1, with a total (90)Y activity of 3 GBq was used. Measurements were performed for one week (0, 3, 5 and 7 d). he acquisition protocol consisted of 30 min-2 bed positions and 120 min-single bed position. mages were reconstructed with 3D ordered subset expectation maximization (OSEM) and point spread function (PSF) for iteration numbers of 1–12 with 21 (TOF) and 24 (non-TOF) subsets and CT based attenuation and scatter correction. Convergence of algorithms and activity recovery was assessed based on regions-of-interest (ROI) analysis of the background (100 voxels), spheres (4 voxels) and the central low density insert (25 voxels). For the largest sphere, the recovery coefficient (RC) values for the 30 min –2-bed position, 30 min-single bed and 120 min-single bed were 1.12±0.20, 1.14±0.13, 0.97±0.07 respectively. For the smaller diameter spheres, the PSF algorithm with TOF and single bed acquisition provided a comparatively better activity recovery. Quantification of Y-90 using Biograph mCT PET/CT is possible with a reasonable accuracy, the limitations being the size of the lesion and the activity concentration present. At this stage, based on our study, it seems advantageous to use different protocols depending on the size of the lesion. Public Library of Science 2014-11-04 /pmc/articles/PMC4219690/ /pubmed/25369020 http://dx.doi.org/10.1371/journal.pone.0110401 Text en © 2014 Attarwala et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Attarwala, Ali Asgar Molina-Duran, Flavia Büsing, Karen-Anett Schönberg, Stefan O. Bailey, Dale L. Willowson, Kathy Glatting, Gerhard Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title | Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title_full | Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title_fullStr | Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title_full_unstemmed | Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title_short | Quantitative and Qualitative Assessment of Yttrium-90 PET/CT Imaging |
title_sort | quantitative and qualitative assessment of yttrium-90 pet/ct imaging |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219690/ https://www.ncbi.nlm.nih.gov/pubmed/25369020 http://dx.doi.org/10.1371/journal.pone.0110401 |
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