Cargando…

Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis

PURPOSE: Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based s...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, E, Sun, Hongpeng, Xu, Yong, Ma, Yana, Zhu, Hong, Pan, Chen-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219834/
https://www.ncbi.nlm.nih.gov/pubmed/25369040
http://dx.doi.org/10.1371/journal.pone.0112054
_version_ 1782342650577289216
author Song, E
Sun, Hongpeng
Xu, Yong
Ma, Yana
Zhu, Hong
Pan, Chen-Wei
author_facet Song, E
Sun, Hongpeng
Xu, Yong
Ma, Yana
Zhu, Hong
Pan, Chen-Wei
author_sort Song, E
collection PubMed
description PURPOSE: Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies. METHODS: We searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model. RESULTS: Totally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P<0.001; I(2) = 64.2%). In the meta-analysis of 9 study findings, adults with nuclear cataract were at higher risks of mortality (pooled HR: 1.55, 95% CI, 1.17, 2.05; P = 0.002; I(2) = 89.2%). In the meta-analysis of 8 study findings, cortical cataract was associated with higher risks of mortality (pooled HR: 1.26, 95% CI, 1.12, 1.42; P<0.001, I(2) = 29.7%). In the meta-analysis of 6 study findings, PSC cataract was associated with higher risks of mortality (pooled HR: 1.37, 95% CI, 1.04, 1.80; P = 0.03; I(2) = 67.3%). The association between cataract surgery and mortality was marginally non-significant by pooling 8 study findings (pooled HR: 1.27, 95% CI, 0.97, 1.66; P = 0.08; I(2) = 76.6%). CONCLUSIONS: All subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the 3 cataract subtypes. However, cataract surgery was not significantly related to mortality. These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population.
format Online
Article
Text
id pubmed-4219834
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-42198342014-11-12 Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis Song, E Sun, Hongpeng Xu, Yong Ma, Yana Zhu, Hong Pan, Chen-Wei PLoS One Research Article PURPOSE: Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies. METHODS: We searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model. RESULTS: Totally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P<0.001; I(2) = 64.2%). In the meta-analysis of 9 study findings, adults with nuclear cataract were at higher risks of mortality (pooled HR: 1.55, 95% CI, 1.17, 2.05; P = 0.002; I(2) = 89.2%). In the meta-analysis of 8 study findings, cortical cataract was associated with higher risks of mortality (pooled HR: 1.26, 95% CI, 1.12, 1.42; P<0.001, I(2) = 29.7%). In the meta-analysis of 6 study findings, PSC cataract was associated with higher risks of mortality (pooled HR: 1.37, 95% CI, 1.04, 1.80; P = 0.03; I(2) = 67.3%). The association between cataract surgery and mortality was marginally non-significant by pooling 8 study findings (pooled HR: 1.27, 95% CI, 0.97, 1.66; P = 0.08; I(2) = 76.6%). CONCLUSIONS: All subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the 3 cataract subtypes. However, cataract surgery was not significantly related to mortality. These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population. Public Library of Science 2014-11-04 /pmc/articles/PMC4219834/ /pubmed/25369040 http://dx.doi.org/10.1371/journal.pone.0112054 Text en © 2014 Song et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Song, E
Sun, Hongpeng
Xu, Yong
Ma, Yana
Zhu, Hong
Pan, Chen-Wei
Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title_full Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title_fullStr Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title_full_unstemmed Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title_short Age-Related Cataract, Cataract Surgery and Subsequent Mortality: A Systematic Review and Meta-Analysis
title_sort age-related cataract, cataract surgery and subsequent mortality: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219834/
https://www.ncbi.nlm.nih.gov/pubmed/25369040
http://dx.doi.org/10.1371/journal.pone.0112054
work_keys_str_mv AT songe agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis
AT sunhongpeng agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis
AT xuyong agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis
AT mayana agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis
AT zhuhong agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis
AT panchenwei agerelatedcataractcataractsurgeryandsubsequentmortalityasystematicreviewandmetaanalysis