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The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity
BACKGROUND/AIMS: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate the feasibility of chest computed tomography (CT) as a diagnostic tool for APT and to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219964/ https://www.ncbi.nlm.nih.gov/pubmed/25378973 http://dx.doi.org/10.3904/kjim.2014.29.6.746 |
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author | Kang, In Sook Kim, Kyung Jin Kim, Yookyung Park, Seong-Hoon |
author_facet | Kang, In Sook Kim, Kyung Jin Kim, Yookyung Park, Seong-Hoon |
author_sort | Kang, In Sook |
collection | PubMed |
description | BACKGROUND/AIMS: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate the feasibility of chest computed tomography (CT) as a diagnostic tool for APT and to assess the utility of the CT APT score as an index for predicting the severity of APT. METHODS: Patients underwent amiodarone treatment for various reasons, most often atrial fibrillation, for more than 2 years, and those that received a cumulative dose > 100 g were enrolled. A total of 34 patients who underwent chest CT between December 2011 and June 2012 were enrolled, whether or not they had clinical symptoms. The APT CT score was defined as the number of involved regions in the lung, which was divided into 18 regions (right and left, upper, middle, and lower, and central, middle, and peripheral). The CT findings were evaluated according to the total dose and duration of amiodarone treatment and the results of a pulmonary function test. Clinical symptoms and outcomes were also evaluated according to APT CT scores. RESULTS: Seven patients had positive APT CT scores (interstitial fibrosis in five, organizing pneumonia in one, and mixed interstitial fibrosis and organizing pneumonia in one), and these patients exhibited significantly lower diffusion capacity for carbon monoxide in the lungs compared with patients without an increased APT CT score (70.2% ± 6.9% vs. 89.7% ± 19.4%; p = 0.011). Three of the seven patients experienced overt APT that required hospital admission. CONCLUSIONS: Chest CT is a useful diagnostic tool for APT, and the APT CT score might be a useful index for assessing the severity of APT. |
format | Online Article Text |
id | pubmed-4219964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-42199642014-11-06 The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity Kang, In Sook Kim, Kyung Jin Kim, Yookyung Park, Seong-Hoon Korean J Intern Med Original Article BACKGROUND/AIMS: Amiodarone is one of the most widely used antiarrhythmic agents; however, amiodarone-induced pulmonary toxicity (APT) can be irreversible and sometimes fatal. The aim of this study was to evaluate the feasibility of chest computed tomography (CT) as a diagnostic tool for APT and to assess the utility of the CT APT score as an index for predicting the severity of APT. METHODS: Patients underwent amiodarone treatment for various reasons, most often atrial fibrillation, for more than 2 years, and those that received a cumulative dose > 100 g were enrolled. A total of 34 patients who underwent chest CT between December 2011 and June 2012 were enrolled, whether or not they had clinical symptoms. The APT CT score was defined as the number of involved regions in the lung, which was divided into 18 regions (right and left, upper, middle, and lower, and central, middle, and peripheral). The CT findings were evaluated according to the total dose and duration of amiodarone treatment and the results of a pulmonary function test. Clinical symptoms and outcomes were also evaluated according to APT CT scores. RESULTS: Seven patients had positive APT CT scores (interstitial fibrosis in five, organizing pneumonia in one, and mixed interstitial fibrosis and organizing pneumonia in one), and these patients exhibited significantly lower diffusion capacity for carbon monoxide in the lungs compared with patients without an increased APT CT score (70.2% ± 6.9% vs. 89.7% ± 19.4%; p = 0.011). Three of the seven patients experienced overt APT that required hospital admission. CONCLUSIONS: Chest CT is a useful diagnostic tool for APT, and the APT CT score might be a useful index for assessing the severity of APT. The Korean Association of Internal Medicine 2014-11 2014-10-31 /pmc/articles/PMC4219964/ /pubmed/25378973 http://dx.doi.org/10.3904/kjim.2014.29.6.746 Text en Copyright © 2014 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, In Sook Kim, Kyung Jin Kim, Yookyung Park, Seong-Hoon The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title | The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title_full | The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title_fullStr | The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title_full_unstemmed | The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title_short | The diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
title_sort | diagnostic utility of chest computed tomography scoring for the assessment of amiodarone-induced pulmonary toxicity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219964/ https://www.ncbi.nlm.nih.gov/pubmed/25378973 http://dx.doi.org/10.3904/kjim.2014.29.6.746 |
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