A new pma1 mutation identified in a chronologically long-lived fission yeast mutant

We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1(+) that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fissio...

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Detalles Bibliográficos
Autores principales: Naito, Chikako, Ito, Hirokazu, Oshiro, Tomoko, Ohtsuka, Hokuto, Murakami, Hiroshi, Aiba, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219986/
https://www.ncbi.nlm.nih.gov/pubmed/25379379
http://dx.doi.org/10.1016/j.fob.2014.09.006
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author Naito, Chikako
Ito, Hirokazu
Oshiro, Tomoko
Ohtsuka, Hokuto
Murakami, Hiroshi
Aiba, Hirofumi
author_facet Naito, Chikako
Ito, Hirokazu
Oshiro, Tomoko
Ohtsuka, Hokuto
Murakami, Hiroshi
Aiba, Hirofumi
author_sort Naito, Chikako
collection PubMed
description We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1(+) that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1.
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spelling pubmed-42199862014-11-06 A new pma1 mutation identified in a chronologically long-lived fission yeast mutant Naito, Chikako Ito, Hirokazu Oshiro, Tomoko Ohtsuka, Hokuto Murakami, Hiroshi Aiba, Hirofumi FEBS Open Bio Article We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1(+) that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1 activity, concomitant with an increase in the chronological lifespan of this fission yeast. This study corroborates our previous report indicating Pma1 activity is crucial for the determination of life span of fission yeast, and offers information for better understanding of the enzyme, Pma1. Elsevier 2014-09-28 /pmc/articles/PMC4219986/ /pubmed/25379379 http://dx.doi.org/10.1016/j.fob.2014.09.006 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Naito, Chikako
Ito, Hirokazu
Oshiro, Tomoko
Ohtsuka, Hokuto
Murakami, Hiroshi
Aiba, Hirofumi
A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title_full A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title_fullStr A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title_full_unstemmed A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title_short A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
title_sort new pma1 mutation identified in a chronologically long-lived fission yeast mutant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219986/
https://www.ncbi.nlm.nih.gov/pubmed/25379379
http://dx.doi.org/10.1016/j.fob.2014.09.006
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