Multiple roles for Na(V)1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease–derived stimuli

Chronic visceral pain affects millions of individuals worldwide and remains poorly understood, with current therapeutic options constrained by gastrointestinal adverse effects. Visceral pain is strongly associated with inflammation and distension of the gut. Here we report that the voltage-gated sod...

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Detalles Bibliográficos
Autores principales: Hockley, James R.F., Boundouki, George, Cibert-Goton, Vincent, McGuire, Cian, Yip, Ping K., Chan, Christopher, Tranter, Michael, Wood, John N., Nassar, Mohammed A., Blackshaw, L. Ashley, Aziz, Qasim, Michael, Gregory J., Baker, Mark D., Winchester, Wendy J., Knowles, Charles H., Bulmer, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220011/
https://www.ncbi.nlm.nih.gov/pubmed/24972070
http://dx.doi.org/10.1016/j.pain.2014.06.015

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