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The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors

VUF10166 (2-chloro-3-(4-methyl piperazin-1-yl)quinoxaline) is a ligand that binds with high affinity to 5-HT(3) receptors. Here we synthesise [(3)H]VUF10166 and characterise its binding properties at 5-HT(3)A and 5-HT(3)AB receptors. At 5-HT(3)A receptors [(3)H]VUF10166 displayed saturable binding w...

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Detalles Bibliográficos
Autores principales:	Thompson, Andrew J., Verheij, Mark H.P., Verbeek, Joost, Windhorst, Albert D., de Esch, Iwan J.P., Lummis, Sarah C.R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220016/ https://www.ncbi.nlm.nih.gov/pubmed/25174552 http://dx.doi.org/10.1016/j.neuropharm.2014.08.008

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