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Tanshinone II-A sodium sulfonate (DS-201) enhances human BK(Ca) channel activity by selectively targeting the pore-forming α subunit

AIM: Tanshinone II-A sodium sulfonate (DS-201), a water-soluble derivative of Tanshinone II-A, has been found to induce vascular relaxation and activate BK(Ca) channels. The aim of this study was to explore the mechanisms underlying the action of DS-201 on BK(Ca) channels. METHODS: Human BK(Ca) chan...

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Detalles Bibliográficos
Autores principales:	Tan, Xiao-qiu, Cheng, Xiu-li, Yang, Yan, Yan, Li, Gu, Jing-li, Li, Hui, Zeng, Xiao-rong, Cao, Ji-min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220078/ https://www.ncbi.nlm.nih.gov/pubmed/25345746 http://dx.doi.org/10.1038/aps.2014.85

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