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Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice
Rapamycin, an allosteric inhibitor of the mTOR kinase, increases longevity in mice in a sex-specific manner. In contrast to the widely accepted theory that a loss of proteasome activity is detrimental to both life- and healthspan, biochemical studies in vitro reveal that rapamycin inhibits 20S prote...
Autores principales: | Rodriguez, Karl A., Dodds, Sherry G., Strong, Randy, Galvan, Veronica, Sharp, Z. D., Buffenstein, Rochelle |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220119/ https://www.ncbi.nlm.nih.gov/pubmed/25414638 http://dx.doi.org/10.3389/fnmol.2014.00083 |
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