Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis

Taspase1, a highly conserved threonine protease, cleaves nuclear transcriptional regulators mixed-lineage leukemia (MLL, MLL1), MLL2, TFIIA, and ALF to orchestrate a wide variety of biological processes. In vitro studies thus far demonstrated that Taspase1 plays important roles in the proliferation...

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Detalles Bibliográficos
Autores principales: Dong, Yiyu, Van Tine, Brian A, Oyama, Toshinao, Wang, Patricia I, Cheng, Emily H, Hsieh, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220155/
https://www.ncbi.nlm.nih.gov/pubmed/25267403
http://dx.doi.org/10.1038/cr.2014.129

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