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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464/ https://www.ncbi.nlm.nih.gov/pubmed/25350695 http://dx.doi.org/10.1038/ncomms6068 |
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| author | Postmus, Iris Trompet, Stella Deshmukh, Harshal A. Barnes, Michael R. Li, Xiaohui Warren, Helen R. Chasman, Daniel I. Zhou, Kaixin Arsenault, Benoit J. Donnelly, Louise A. Wiggins, Kerri L. Avery, Christy L. Griffin, Paula Feng, QiPing Taylor, Kent D. Li, Guo Evans, Daniel S. Smith, Albert V. de Keyser, Catherine E. Johnson, Andrew D. de Craen, Anton J. M. Stott, David J. Buckley, Brendan M. Ford, Ian Westendorp, Rudi G. J. Eline Slagboom, P. Sattar, Naveed Munroe, Patricia B. Sever, Peter Poulter, Neil Stanton, Alice Shields, Denis C. O’Brien, Eoin Shaw-Hawkins, Sue Ida Chen, Y.-D. Nickerson, Deborah A. Smith, Joshua D. Pierre Dubé, Marie Matthijs Boekholdt, S. Kees Hovingh, G. Kastelein, John J. P. McKeigue, Paul M. Betteridge, John Neil, Andrew Durrington, Paul N. Doney, Alex Carr, Fiona Morris, Andrew McCarthy, Mark I. Groop, Leif Ahlqvist, Emma Bis, Joshua C. Rice, Kenneth Smith, Nicholas L. Lumley, Thomas Whitsel, Eric A. Stürmer, Til Boerwinkle, Eric Ngwa, Julius S. O’Donnell, Christopher J. Vasan, Ramachandran S. Wei, Wei-Qi Wilke, Russell A. Liu, Ching-Ti Sun, Fangui Guo, Xiuqing Heckbert, Susan R Post, Wendy Sotoodehnia, Nona Arnold, Alice M. Stafford, Jeanette M. Ding, Jingzhong Herrington, David M. Kritchevsky, Stephen B. Eiriksdottir, Gudny Launer, Leonore J. Harris, Tamara B. Chu, Audrey Y. Giulianini, Franco MacFadyen, Jean G. Barratt, Bryan J. Nyberg, Fredrik Stricker, Bruno H. Uitterlinden, André G. Hofman, Albert Rivadeneira, Fernando Emilsson, Valur Franco, Oscar H. Ridker, Paul M. Gudnason, Vilmundur Liu, Yongmei Denny, Joshua C. Ballantyne, Christie M. Rotter, Jerome I. Adrienne Cupples, L. Psaty, Bruce M. Palmer, Colin N. A. Tardif, Jean-Claude Colhoun, Helen M. Hitman, Graham Krauss, Ronald M. Wouter Jukema, J Caulfield, Mark J. |
| author_facet | Postmus, Iris Trompet, Stella Deshmukh, Harshal A. Barnes, Michael R. Li, Xiaohui Warren, Helen R. Chasman, Daniel I. Zhou, Kaixin Arsenault, Benoit J. Donnelly, Louise A. Wiggins, Kerri L. Avery, Christy L. Griffin, Paula Feng, QiPing Taylor, Kent D. Li, Guo Evans, Daniel S. Smith, Albert V. de Keyser, Catherine E. Johnson, Andrew D. de Craen, Anton J. M. Stott, David J. Buckley, Brendan M. Ford, Ian Westendorp, Rudi G. J. Eline Slagboom, P. Sattar, Naveed Munroe, Patricia B. Sever, Peter Poulter, Neil Stanton, Alice Shields, Denis C. O’Brien, Eoin Shaw-Hawkins, Sue Ida Chen, Y.-D. Nickerson, Deborah A. Smith, Joshua D. Pierre Dubé, Marie Matthijs Boekholdt, S. Kees Hovingh, G. Kastelein, John J. P. McKeigue, Paul M. Betteridge, John Neil, Andrew Durrington, Paul N. Doney, Alex Carr, Fiona Morris, Andrew McCarthy, Mark I. Groop, Leif Ahlqvist, Emma Bis, Joshua C. Rice, Kenneth Smith, Nicholas L. Lumley, Thomas Whitsel, Eric A. Stürmer, Til Boerwinkle, Eric Ngwa, Julius S. O’Donnell, Christopher J. Vasan, Ramachandran S. Wei, Wei-Qi Wilke, Russell A. Liu, Ching-Ti Sun, Fangui Guo, Xiuqing Heckbert, Susan R Post, Wendy Sotoodehnia, Nona Arnold, Alice M. Stafford, Jeanette M. Ding, Jingzhong Herrington, David M. Kritchevsky, Stephen B. Eiriksdottir, Gudny Launer, Leonore J. Harris, Tamara B. Chu, Audrey Y. Giulianini, Franco MacFadyen, Jean G. Barratt, Bryan J. Nyberg, Fredrik Stricker, Bruno H. Uitterlinden, André G. Hofman, Albert Rivadeneira, Fernando Emilsson, Valur Franco, Oscar H. Ridker, Paul M. Gudnason, Vilmundur Liu, Yongmei Denny, Joshua C. Ballantyne, Christie M. Rotter, Jerome I. Adrienne Cupples, L. Psaty, Bruce M. Palmer, Colin N. A. Tardif, Jean-Claude Colhoun, Helen M. Hitman, Graham Krauss, Ronald M. Wouter Jukema, J Caulfield, Mark J. |
| author_sort | Postmus, Iris |
| collection | PubMed |
| description | Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response. |
| format | Online Article Text |
| id | pubmed-4220464 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Nature Pub. Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-42204642014-11-13 Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins Postmus, Iris Trompet, Stella Deshmukh, Harshal A. Barnes, Michael R. Li, Xiaohui Warren, Helen R. Chasman, Daniel I. Zhou, Kaixin Arsenault, Benoit J. Donnelly, Louise A. Wiggins, Kerri L. Avery, Christy L. Griffin, Paula Feng, QiPing Taylor, Kent D. Li, Guo Evans, Daniel S. Smith, Albert V. de Keyser, Catherine E. Johnson, Andrew D. de Craen, Anton J. M. Stott, David J. Buckley, Brendan M. Ford, Ian Westendorp, Rudi G. J. Eline Slagboom, P. Sattar, Naveed Munroe, Patricia B. Sever, Peter Poulter, Neil Stanton, Alice Shields, Denis C. O’Brien, Eoin Shaw-Hawkins, Sue Ida Chen, Y.-D. Nickerson, Deborah A. Smith, Joshua D. Pierre Dubé, Marie Matthijs Boekholdt, S. Kees Hovingh, G. Kastelein, John J. P. McKeigue, Paul M. Betteridge, John Neil, Andrew Durrington, Paul N. Doney, Alex Carr, Fiona Morris, Andrew McCarthy, Mark I. Groop, Leif Ahlqvist, Emma Bis, Joshua C. Rice, Kenneth Smith, Nicholas L. Lumley, Thomas Whitsel, Eric A. Stürmer, Til Boerwinkle, Eric Ngwa, Julius S. O’Donnell, Christopher J. Vasan, Ramachandran S. Wei, Wei-Qi Wilke, Russell A. Liu, Ching-Ti Sun, Fangui Guo, Xiuqing Heckbert, Susan R Post, Wendy Sotoodehnia, Nona Arnold, Alice M. Stafford, Jeanette M. Ding, Jingzhong Herrington, David M. Kritchevsky, Stephen B. Eiriksdottir, Gudny Launer, Leonore J. Harris, Tamara B. Chu, Audrey Y. Giulianini, Franco MacFadyen, Jean G. Barratt, Bryan J. Nyberg, Fredrik Stricker, Bruno H. Uitterlinden, André G. Hofman, Albert Rivadeneira, Fernando Emilsson, Valur Franco, Oscar H. Ridker, Paul M. Gudnason, Vilmundur Liu, Yongmei Denny, Joshua C. Ballantyne, Christie M. Rotter, Jerome I. Adrienne Cupples, L. Psaty, Bruce M. Palmer, Colin N. A. Tardif, Jean-Claude Colhoun, Helen M. Hitman, Graham Krauss, Ronald M. Wouter Jukema, J Caulfield, Mark J. Nat Commun Article Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response. Nature Pub. Group 2014-10-28 /pmc/articles/PMC4220464/ /pubmed/25350695 http://dx.doi.org/10.1038/ncomms6068 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Postmus, Iris Trompet, Stella Deshmukh, Harshal A. Barnes, Michael R. Li, Xiaohui Warren, Helen R. Chasman, Daniel I. Zhou, Kaixin Arsenault, Benoit J. Donnelly, Louise A. Wiggins, Kerri L. Avery, Christy L. Griffin, Paula Feng, QiPing Taylor, Kent D. Li, Guo Evans, Daniel S. Smith, Albert V. de Keyser, Catherine E. Johnson, Andrew D. de Craen, Anton J. M. Stott, David J. Buckley, Brendan M. Ford, Ian Westendorp, Rudi G. J. Eline Slagboom, P. Sattar, Naveed Munroe, Patricia B. Sever, Peter Poulter, Neil Stanton, Alice Shields, Denis C. O’Brien, Eoin Shaw-Hawkins, Sue Ida Chen, Y.-D. Nickerson, Deborah A. Smith, Joshua D. Pierre Dubé, Marie Matthijs Boekholdt, S. Kees Hovingh, G. Kastelein, John J. P. McKeigue, Paul M. Betteridge, John Neil, Andrew Durrington, Paul N. Doney, Alex Carr, Fiona Morris, Andrew McCarthy, Mark I. Groop, Leif Ahlqvist, Emma Bis, Joshua C. Rice, Kenneth Smith, Nicholas L. Lumley, Thomas Whitsel, Eric A. Stürmer, Til Boerwinkle, Eric Ngwa, Julius S. O’Donnell, Christopher J. Vasan, Ramachandran S. Wei, Wei-Qi Wilke, Russell A. Liu, Ching-Ti Sun, Fangui Guo, Xiuqing Heckbert, Susan R Post, Wendy Sotoodehnia, Nona Arnold, Alice M. Stafford, Jeanette M. Ding, Jingzhong Herrington, David M. Kritchevsky, Stephen B. Eiriksdottir, Gudny Launer, Leonore J. Harris, Tamara B. Chu, Audrey Y. Giulianini, Franco MacFadyen, Jean G. Barratt, Bryan J. Nyberg, Fredrik Stricker, Bruno H. Uitterlinden, André G. Hofman, Albert Rivadeneira, Fernando Emilsson, Valur Franco, Oscar H. Ridker, Paul M. Gudnason, Vilmundur Liu, Yongmei Denny, Joshua C. Ballantyne, Christie M. Rotter, Jerome I. Adrienne Cupples, L. Psaty, Bruce M. Palmer, Colin N. A. Tardif, Jean-Claude Colhoun, Helen M. Hitman, Graham Krauss, Ronald M. Wouter Jukema, J Caulfield, Mark J. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_full | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_fullStr | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_full_unstemmed | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_short | Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins |
| title_sort | pharmacogenetic meta-analysis of genome-wide association studies of ldl cholesterol response to statins |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220464/ https://www.ncbi.nlm.nih.gov/pubmed/25350695 http://dx.doi.org/10.1038/ncomms6068 |
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