Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold....

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Detalles Bibliográficos
Autores principales: Desmet, Johan, Verstraete, Kenneth, Bloch, Yehudi, Lorent, Eric, Wen, Yurong, Devreese, Bart, Vandenbroucke, Karen, Loverix, Stefan, Hettmann, Thore, Deroo, Sabrina, Somers, Klaartje, Henderikx, Paula, Lasters, Ignace, Savvides, Savvas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220489/
https://www.ncbi.nlm.nih.gov/pubmed/25354530
http://dx.doi.org/10.1038/ncomms6237

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