Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy

The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of clas...

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Autores principales: Teng, Beina, Duong, Michelle, Tossidou, Irini, Yu, Xuejiao, Schiffer, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220730/
https://www.ncbi.nlm.nih.gov/pubmed/25414693
http://dx.doi.org/10.3389/fendo.2014.00179
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author Teng, Beina
Duong, Michelle
Tossidou, Irini
Yu, Xuejiao
Schiffer, Mario
author_facet Teng, Beina
Duong, Michelle
Tossidou, Irini
Yu, Xuejiao
Schiffer, Mario
author_sort Teng, Beina
collection PubMed
description The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.
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spelling pubmed-42207302014-11-20 Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy Teng, Beina Duong, Michelle Tossidou, Irini Yu, Xuejiao Schiffer, Mario Front Endocrinol (Lausanne) Endocrinology The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes. Frontiers Media S.A. 2014-11-05 /pmc/articles/PMC4220730/ /pubmed/25414693 http://dx.doi.org/10.3389/fendo.2014.00179 Text en Copyright © 2014 Teng, Duong, Tossidou, Yu and Schiffer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Teng, Beina
Duong, Michelle
Tossidou, Irini
Yu, Xuejiao
Schiffer, Mario
Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title_full Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title_fullStr Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title_full_unstemmed Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title_short Role of Protein Kinase C in Podocytes and Development of Glomerular Damage in Diabetic Nephropathy
title_sort role of protein kinase c in podocytes and development of glomerular damage in diabetic nephropathy
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220730/
https://www.ncbi.nlm.nih.gov/pubmed/25414693
http://dx.doi.org/10.3389/fendo.2014.00179
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