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Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus
Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory projections from the IC through the MG and on to audito...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220731/ https://www.ncbi.nlm.nih.gov/pubmed/25414646 http://dx.doi.org/10.3389/fnana.2014.00124 |
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author | Mellott, Jeffrey G. Foster, Nichole L. Ohl, Andrew P. Schofield, Brett R. |
author_facet | Mellott, Jeffrey G. Foster, Nichole L. Ohl, Andrew P. Schofield, Brett R. |
author_sort | Mellott, Jeffrey G. |
collection | PubMed |
description | Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory projections from the IC through the MG and on to auditory cortex. A striking discovery about the tectothalamic circuit was identification of a substantial GABAergic component. Whether GABAergic projections match the parallel pathway organization has not been examined. We asked whether the parallel pathway concept is reflected in guinea pig tectothalamic pathways and to what degree GABAergic cells contribute to each pathway. We deposited retrograde tracers into individual MG subdivisions (ventral, MGv; medial, MGm; dorsal, MGd; suprageniculate, MGsg) to label tectothalamic cells and used immunochemistry to identify GABAergic cells. The MGv receives most of its IC input (~75%) from the IC central nucleus (ICc); MGd and MGsg receive most of their input (~70%) from IC dorsal cortex (ICd); and MGm receives substantial input from both ICc (~40%) and IC lateral cortex (~40%). Each MG subdivision receives additional input (up to 32%) from non-dominant IC subdivisions, suggesting cross-talk between the pathways. The proportion of GABAergic cells in each pathway depended on the MG subdivision. GABAergic cells formed ~20% of IC inputs to MGv or MGm, ~11% of inputs to MGd, and 4% of inputs to MGsg. Thus, non-GABAergic (i.e., glutamatergic) cells are most numerous in each pathway with GABAergic cells contributing to different extents. Despite smaller numbers of GABAergic cells, their distributions across IC subdivisions mimicked the parallel pathways. Projections outside the dominant pathways suggest opportunities for excitatory and inhibitory crosstalk. The results demonstrate parallel tectothalamic pathways in guinea pigs and suggest numerous opportunities for excitatory and inhibitory interactions within and between pathways. |
format | Online Article Text |
id | pubmed-4220731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42207312014-11-20 Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus Mellott, Jeffrey G. Foster, Nichole L. Ohl, Andrew P. Schofield, Brett R. Front Neuroanat Neuroscience Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory projections from the IC through the MG and on to auditory cortex. A striking discovery about the tectothalamic circuit was identification of a substantial GABAergic component. Whether GABAergic projections match the parallel pathway organization has not been examined. We asked whether the parallel pathway concept is reflected in guinea pig tectothalamic pathways and to what degree GABAergic cells contribute to each pathway. We deposited retrograde tracers into individual MG subdivisions (ventral, MGv; medial, MGm; dorsal, MGd; suprageniculate, MGsg) to label tectothalamic cells and used immunochemistry to identify GABAergic cells. The MGv receives most of its IC input (~75%) from the IC central nucleus (ICc); MGd and MGsg receive most of their input (~70%) from IC dorsal cortex (ICd); and MGm receives substantial input from both ICc (~40%) and IC lateral cortex (~40%). Each MG subdivision receives additional input (up to 32%) from non-dominant IC subdivisions, suggesting cross-talk between the pathways. The proportion of GABAergic cells in each pathway depended on the MG subdivision. GABAergic cells formed ~20% of IC inputs to MGv or MGm, ~11% of inputs to MGd, and 4% of inputs to MGsg. Thus, non-GABAergic (i.e., glutamatergic) cells are most numerous in each pathway with GABAergic cells contributing to different extents. Despite smaller numbers of GABAergic cells, their distributions across IC subdivisions mimicked the parallel pathways. Projections outside the dominant pathways suggest opportunities for excitatory and inhibitory crosstalk. The results demonstrate parallel tectothalamic pathways in guinea pigs and suggest numerous opportunities for excitatory and inhibitory interactions within and between pathways. Frontiers Media S.A. 2014-11-05 /pmc/articles/PMC4220731/ /pubmed/25414646 http://dx.doi.org/10.3389/fnana.2014.00124 Text en Copyright © 2014 Mellott, Foster, Ohl and Schofield. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Mellott, Jeffrey G. Foster, Nichole L. Ohl, Andrew P. Schofield, Brett R. Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title | Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title_full | Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title_fullStr | Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title_full_unstemmed | Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title_short | Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
title_sort | excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220731/ https://www.ncbi.nlm.nih.gov/pubmed/25414646 http://dx.doi.org/10.3389/fnana.2014.00124 |
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