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Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy?
There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher t...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220799/ https://www.ncbi.nlm.nih.gov/pubmed/24283830 http://dx.doi.org/10.1186/1741-7015-11-251 |
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author | Sabin, Caroline A |
author_facet | Sabin, Caroline A |
author_sort | Sabin, Caroline A |
collection | PubMed |
description | There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expected based on rates seen in the general population. A low CD4 count, whether due to late HIV diagnosis, late initiation of cART, or incomplete adherence to cART, remains the dominant predictor of LE, and thus the individual’s disease stage at initiation of cART (or thereafter) certainly contributes to these higher mortality rates. However, individuals with HIV also tend to exhibit lifestyles and behaviors that place them at increased risk of mortality, particularly from non-AIDS causes. Thus, although mortality rates among the HIV population may indeed remain slightly higher than those seen in the general population, they may be no higher than those seen in a more appropriately matched control group. Thus, further improvements in LE may now only be possible if some of the other underlying issues (for example, modification of lifestyle or behavioral factors) are tackled. |
format | Online Article Text |
id | pubmed-4220799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42207992014-11-06 Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? Sabin, Caroline A BMC Med Review There is evidence that the life expectancy (LE) of individuals infected with the human immunodeficiency virus (HIV) has increased since the introduction of combination antiretroviral therapy (cART). However, mortality rates in recent years in HIV-positive individuals appear to have remained higher than would be expected based on rates seen in the general population. A low CD4 count, whether due to late HIV diagnosis, late initiation of cART, or incomplete adherence to cART, remains the dominant predictor of LE, and thus the individual’s disease stage at initiation of cART (or thereafter) certainly contributes to these higher mortality rates. However, individuals with HIV also tend to exhibit lifestyles and behaviors that place them at increased risk of mortality, particularly from non-AIDS causes. Thus, although mortality rates among the HIV population may indeed remain slightly higher than those seen in the general population, they may be no higher than those seen in a more appropriately matched control group. Thus, further improvements in LE may now only be possible if some of the other underlying issues (for example, modification of lifestyle or behavioral factors) are tackled. BioMed Central 2013-11-27 /pmc/articles/PMC4220799/ /pubmed/24283830 http://dx.doi.org/10.1186/1741-7015-11-251 Text en Copyright © 2013 Sabin; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Sabin, Caroline A Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title | Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title_full | Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title_fullStr | Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title_full_unstemmed | Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title_short | Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? |
title_sort | do people with hiv infection have a normal life expectancy in the era of combination antiretroviral therapy? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220799/ https://www.ncbi.nlm.nih.gov/pubmed/24283830 http://dx.doi.org/10.1186/1741-7015-11-251 |
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