Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo

Lymphocyte Activation Gene – 3 (LAG-3) is an immune checkpoint molecule that regulates both T-cell activation and homeostasis. However, the molecular mechanisms underlying LAG-3’s function are generally unknown. Using a model in which LAG-3 blockade or absence reliably augmented homeostatic prolifer...

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Detalles Bibliográficos
Autores principales: Durham, Nicholas M., Nirschl, Christopher J., Jackson, Christopher M., Elias, Jimmy, Kochel, Christina M., Anders, Robert A., Drake, Charles G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220939/
https://www.ncbi.nlm.nih.gov/pubmed/25372844
http://dx.doi.org/10.1371/journal.pone.0109080

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