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Structural insights into the human RyR2 N-terminal region involved in cardiac arrhythmias

Human ryanodine receptor 2 (hRyR2) mediates calcium release from the sarcoplasmic reticulum, enabling cardiomyocyte contraction. The N-terminal region of hRyR2 (amino acids 1–606) is the target of >30 arrhythmogenic mutations and contains a binding site for phosphoprotein phosphatase 1. Here, th...

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Detalles Bibliográficos
Autores principales:	Borko, Ľubomír, Bauerová-Hlinková, Vladena, Hostinová, Eva, Gašperík, Juraj, Beck, Konrad, Lai, F. Anthony, Zahradníková, Alexandra, Ševčík, Jozef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220973/ https://www.ncbi.nlm.nih.gov/pubmed/25372681 http://dx.doi.org/10.1107/S1399004714020343

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