Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

BACKGROUND: There has been accumulating evidence that there are associations among γ-glutamyltransferase (γ-GT) elevation and all-cause mortality, cardiovascular diseases and metabolic diseases, including nonalcoholic fatty liver disease. The primary objective of this study was to evaluate the impac...

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Detalles Bibliográficos
Autores principales: Ogusu, Naoki, Saruwatari, Junji, Nakashima, Hiroo, Noai, Madoka, Nishimura, Miki, Deguchi, Mariko, Oniki, Kentaro, Yasui-Furukori, Norio, Kaneko, Sunao, Ishitsu, Takateru, Nakagaswa, Kazuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220988/
https://www.ncbi.nlm.nih.gov/pubmed/25372290
http://dx.doi.org/10.1371/journal.pone.0111066

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