Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence

Motivation: The clonal theory of adaptive immunity proposes that immunological responses are encoded by increases in the frequency of lymphocytes carrying antigen-specific receptors. In this study, we measure the frequency of different T-cell receptors (TcR) in CD4 + T cell populations of mice immun...

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Detalles Bibliográficos
Autores principales: Thomas, Niclas, Best, Katharine, Cinelli, Mattia, Reich-Zeliger, Shlomit, Gal, Hilah, Shifrut, Eric, Madi, Asaf, Friedman, Nir, Shawe-Taylor, John, Chain, Benny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221123/
https://www.ncbi.nlm.nih.gov/pubmed/25095879
http://dx.doi.org/10.1093/bioinformatics/btu523

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