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Effect of Piroxicam on ART Outcome: A Pilot Study
BACKGROUND: One of the most important factors affecting success rates in assisted reproductive techniques (ART) besides the number of oocytes retrieved and high quality embryos derived from them is the technical aspects of embryo transfer. It seems that pretreatement with uterine relaxants can be he...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221509/ https://www.ncbi.nlm.nih.gov/pubmed/25379151 |
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author | Sohrabvand, Farnaz Haghollahi, Fedyeh Maasomi, Masoomeh Shariat, Mamak |
author_facet | Sohrabvand, Farnaz Haghollahi, Fedyeh Maasomi, Masoomeh Shariat, Mamak |
author_sort | Sohrabvand, Farnaz |
collection | PubMed |
description | BACKGROUND: One of the most important factors affecting success rates in assisted reproductive techniques (ART) besides the number of oocytes retrieved and high quality embryos derived from them is the technical aspects of embryo transfer. It seems that pretreatement with uterine relaxants can be helpful in preventing un- pleasant cramps which can have an adverse effect on ART outcome. In this respect, some drugs such as prostaglandin inhibitors or sedatives have been evaluated but not confirmed yet remain controversial. This study was performed in order to assess the effect of administrating Piroxicam prior to embryo transfer on pregnancy rates in ART cycles. MATERIALS AND METHODS: This pilot study was performed from August 2010 through December 2011 on 50 infertile women in ART cycles. Recombinant follicle stimulating hormone (rFSH) with a long gonadotropin releasing hormone (GnRH) analogue protocol were used for controlled ovarian hyperstimulation. The subjects were randomly allocated into two groups of 25 patients after obtaining written consent. Group A received a 10 mg Piroxicam capsule 30 minutes before embryo transfer and group B was the control group with no treatment. Data were analyzed by Chi-square and analysis of variance (ANOVA). RESULTS: Pregnancy rate was 34% (n=17) totally, with 32% (n=8) in group A and 36% (n=9) in group B (p=0.75). Uterine cramps were experienced by 4 women (16%) in group B, while none were reported by women in group A (p=0.037). CONCLUSION: It seems that Piroxicam administration 30 minutes prior to embryo transfer can- not increase pregnancy rates, but can prevent or reduce uterine cramps after the procedure. |
format | Online Article Text |
id | pubmed-4221509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-42215092014-11-06 Effect of Piroxicam on ART Outcome: A Pilot Study Sohrabvand, Farnaz Haghollahi, Fedyeh Maasomi, Masoomeh Shariat, Mamak Int J Fertil Steril Original Article BACKGROUND: One of the most important factors affecting success rates in assisted reproductive techniques (ART) besides the number of oocytes retrieved and high quality embryos derived from them is the technical aspects of embryo transfer. It seems that pretreatement with uterine relaxants can be helpful in preventing un- pleasant cramps which can have an adverse effect on ART outcome. In this respect, some drugs such as prostaglandin inhibitors or sedatives have been evaluated but not confirmed yet remain controversial. This study was performed in order to assess the effect of administrating Piroxicam prior to embryo transfer on pregnancy rates in ART cycles. MATERIALS AND METHODS: This pilot study was performed from August 2010 through December 2011 on 50 infertile women in ART cycles. Recombinant follicle stimulating hormone (rFSH) with a long gonadotropin releasing hormone (GnRH) analogue protocol were used for controlled ovarian hyperstimulation. The subjects were randomly allocated into two groups of 25 patients after obtaining written consent. Group A received a 10 mg Piroxicam capsule 30 minutes before embryo transfer and group B was the control group with no treatment. Data were analyzed by Chi-square and analysis of variance (ANOVA). RESULTS: Pregnancy rate was 34% (n=17) totally, with 32% (n=8) in group A and 36% (n=9) in group B (p=0.75). Uterine cramps were experienced by 4 women (16%) in group B, while none were reported by women in group A (p=0.037). CONCLUSION: It seems that Piroxicam administration 30 minutes prior to embryo transfer can- not increase pregnancy rates, but can prevent or reduce uterine cramps after the procedure. Royan Institute 2014 2014-11-01 /pmc/articles/PMC4221509/ /pubmed/25379151 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sohrabvand, Farnaz Haghollahi, Fedyeh Maasomi, Masoomeh Shariat, Mamak Effect of Piroxicam on ART Outcome: A Pilot Study |
title | Effect of Piroxicam on ART Outcome: A Pilot Study |
title_full | Effect of Piroxicam on ART Outcome: A Pilot Study |
title_fullStr | Effect of Piroxicam on ART Outcome: A Pilot Study |
title_full_unstemmed | Effect of Piroxicam on ART Outcome: A Pilot Study |
title_short | Effect of Piroxicam on ART Outcome: A Pilot Study |
title_sort | effect of piroxicam on art outcome: a pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221509/ https://www.ncbi.nlm.nih.gov/pubmed/25379151 |
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