Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa me...

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Detalles Bibliográficos
Autores principales: Jin, Jung-Kang, Tien, Pei-Chieh, Cheng, Chien-Jui, Song, Jian H., Huang, Cai, Lin, Sue-Hwa, Gallick, Gary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221586/
https://www.ncbi.nlm.nih.gov/pubmed/24793790
http://dx.doi.org/10.1038/onc.2014.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221586/
https://www.ncbi.nlm.nih.gov/pubmed/24793790
http://dx.doi.org/10.1038/onc.2014.116

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