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NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

NPRL-Z-1 is a 4β-[(4″-benzamido)-amino]-4′-O-demethyl-epipodophyllotoxin derivative. Previous reports have shown that NPRL-Z-1 possesses anticancer activity. Here NPRL-Z-1 displayed cytotoxic effects against four human cancer cell lines (HCT 116, A549, ACHN, and A498) and exhibited potent activity i...

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Detalles Bibliográficos
Autores principales:	Wu, Szu-Ying, Pan, Shiow-Lin, Xiao, Zhi-Yan, Hsu, Jui-Ling, Chen, Mei-Chuan, Lee, Kuo-Hsiung, Teng, Che-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221609/ https://www.ncbi.nlm.nih.gov/pubmed/25372714 http://dx.doi.org/10.1371/journal.pone.0112220

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