The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence

BACKGROUND: The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM helicase when DNA synthesis is prohibited. Keeping the replication machinery...

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Detalles Bibliográficos
Autores principales: Uzunova, Sonya Dimitrova, Zarkov, Alexander Stefanov, Ivanova, Anna Marianova, Stoynov, Stoyno Stefanov, Nedelcheva-Veleva, Marina Nedelcheva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221646/
https://www.ncbi.nlm.nih.gov/pubmed/25379053
http://dx.doi.org/10.1186/1747-1028-9-4

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