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FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling

BACKGROUND: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. FTY720, a new immunos...

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Detalles Bibliográficos
Autores principales:	Lu, Zhaoyang, Wang, Jiabei, Zheng, Tongsen, Liang, Yingjian, Yin, Dalong, Song, Ruipeng, Pei, Tiemin, Pan, Shangha, Jiang, Hongchi, Liu, Lianxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221672/ https://www.ncbi.nlm.nih.gov/pubmed/25344679 http://dx.doi.org/10.1186/1471-2407-14-783

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