Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells

BACKGROUND: Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug resistance remain unknown. RESULTS: To explore a potential role for altered cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yuting, Daemen, Anneleen, Hatzivassiliou, Georgia, Arnott, David, Wilson, Catherine, Zhuang, Guanglei, Gao, Min, Liu, Peter, Boudreau, Aaron, Johnson, Leisa, Settleman, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221711/
https://www.ncbi.nlm.nih.gov/pubmed/25379179
http://dx.doi.org/10.1186/2049-3002-2-20

Ejemplares similares

Ejemplares similares