Cryptosporidium cuniculus - new records in human and kangaroo in Australia

BACKGROUND: To date, Cryptosporidium cuniculus has been found exclusively in rabbits and humans. The present study provides the first published molecular evidence for C. cuniculus in an Australian human patient as well as a kangaroo. FINDINGS: Using PCR-based sequencing of regions in the actin, 60 k...

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Autores principales: Koehler, Anson V, Whipp, Margaret J, Haydon, Shane R, Gasser, Robin B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221722/
https://www.ncbi.nlm.nih.gov/pubmed/25359081
http://dx.doi.org/10.1186/s13071-014-0492-8
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author Koehler, Anson V
Whipp, Margaret J
Haydon, Shane R
Gasser, Robin B
author_facet Koehler, Anson V
Whipp, Margaret J
Haydon, Shane R
Gasser, Robin B
author_sort Koehler, Anson V
collection PubMed
description BACKGROUND: To date, Cryptosporidium cuniculus has been found exclusively in rabbits and humans. The present study provides the first published molecular evidence for C. cuniculus in an Australian human patient as well as a kangaroo. FINDINGS: Using PCR-based sequencing of regions in the actin, 60 kDa glycoprotein (gp60) and small subunit of ribosomal RNA (SSU) genes, we identified a new and unique C. cuniculus genotype (akin to VbA25) from a human, and C. cuniculus genotype VbA26 from an Eastern grey kangaroo (Macropus giganteus) in Australia. CONCLUSIONS: The characterisation of these genotypes raises questions as to their potential to infect humans and/or other animals in Australia, given that C. cuniculus has been reported to cause cryptosporidiosis outbreaks in Europe.
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spelling pubmed-42217222014-11-07 Cryptosporidium cuniculus - new records in human and kangaroo in Australia Koehler, Anson V Whipp, Margaret J Haydon, Shane R Gasser, Robin B Parasit Vectors Short Report BACKGROUND: To date, Cryptosporidium cuniculus has been found exclusively in rabbits and humans. The present study provides the first published molecular evidence for C. cuniculus in an Australian human patient as well as a kangaroo. FINDINGS: Using PCR-based sequencing of regions in the actin, 60 kDa glycoprotein (gp60) and small subunit of ribosomal RNA (SSU) genes, we identified a new and unique C. cuniculus genotype (akin to VbA25) from a human, and C. cuniculus genotype VbA26 from an Eastern grey kangaroo (Macropus giganteus) in Australia. CONCLUSIONS: The characterisation of these genotypes raises questions as to their potential to infect humans and/or other animals in Australia, given that C. cuniculus has been reported to cause cryptosporidiosis outbreaks in Europe. BioMed Central 2014-10-30 /pmc/articles/PMC4221722/ /pubmed/25359081 http://dx.doi.org/10.1186/s13071-014-0492-8 Text en © Koehler et al.; licensee BioMed Central Ltd. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Koehler, Anson V
Whipp, Margaret J
Haydon, Shane R
Gasser, Robin B
Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title_full Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title_fullStr Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title_full_unstemmed Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title_short Cryptosporidium cuniculus - new records in human and kangaroo in Australia
title_sort cryptosporidium cuniculus - new records in human and kangaroo in australia
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221722/
https://www.ncbi.nlm.nih.gov/pubmed/25359081
http://dx.doi.org/10.1186/s13071-014-0492-8
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