A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer

The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to c...

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Detalles Bibliográficos
Autores principales: Wang, Yinsheng, Zha, Lidan, Liao, Dan, Li, Xiaozhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221867/
https://www.ncbi.nlm.nih.gov/pubmed/25401099
http://dx.doi.org/10.1155/2014/312102
Descripción
Sumario:The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

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