A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer

The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to c...

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Detalles Bibliográficos
Autores principales: Wang, Yinsheng, Zha, Lidan, Liao, Dan, Li, Xiaozhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221867/
https://www.ncbi.nlm.nih.gov/pubmed/25401099
http://dx.doi.org/10.1155/2014/312102
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author Wang, Yinsheng
Zha, Lidan
Liao, Dan
Li, Xiaozhi
author_facet Wang, Yinsheng
Zha, Lidan
Liao, Dan
Li, Xiaozhi
author_sort Wang, Yinsheng
collection PubMed
description The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.
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spelling pubmed-42218672014-11-16 A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer Wang, Yinsheng Zha, Lidan Liao, Dan Li, Xiaozhi Int J Genomics Research Article The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation. Hindawi Publishing Corporation 2014 2014-10-21 /pmc/articles/PMC4221867/ /pubmed/25401099 http://dx.doi.org/10.1155/2014/312102 Text en Copyright © 2014 Yinsheng Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Yinsheng
Zha, Lidan
Liao, Dan
Li, Xiaozhi
A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title_full A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title_fullStr A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title_full_unstemmed A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title_short A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer
title_sort meta-analysis on the relations between egfr r521k polymorphism and risk of cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221867/
https://www.ncbi.nlm.nih.gov/pubmed/25401099
http://dx.doi.org/10.1155/2014/312102
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