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Rapamycin-induced metabolic defects are reversible in both lean and obese mice

The inhibition of mTOR (mechanistic target of rapamycin) by the macrolide rapamycin has many beneficial effects in mice, including extension of lifespan and reduction or prevention of several age-related diseases. At the same time, chronic rapamycin treatment causes impairments in glucose metabolism...

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Detalles Bibliográficos
Autores principales:	Liu, Yuhong, Diaz, Vivian, Fernandez, Elizabeth, Strong, Randy, Ye, Lan, Baur, Joseph A., Lamming, Dudley W., Richardson, Arlan, Salmon, Adam B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221917/ https://www.ncbi.nlm.nih.gov/pubmed/25324470

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