In silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem-Cell Transplant Donors and Recipients: Understanding the Quantitative Immunobiology of Allogeneic Transplantation

Donor T-cell mediated graft versus host (GVH) effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the human leukocyte antigen (HLA) molecules in each donor–recipient pair undergoing stem-cell transplantation (SCT). Whole exome sequencing has p...

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Detalles Bibliográficos
Autores principales: Jameson-Lee, Max, Koparde, Vishal, Griffith, Phil, Scalora, Allison F., Sampson, Juliana K., Khalid, Haniya, Sheth, Nihar U., Batalo, Michael, Serrano, Myrna G., Roberts, Catherine H., Hess, Michael L., Buck, Gregory A., Neale, Michael C., Manjili, Masoud H., Toor, Amir Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222229/
https://www.ncbi.nlm.nih.gov/pubmed/25414699
http://dx.doi.org/10.3389/fimmu.2014.00529

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