Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

The classical complement pathway is initiated by the large (~800 kDa) and flexible multimeric C1 complex. Its catalytic function is triggered by the proteases hetero-tetramer C1r2s2, which is associated to the C1q sensing unit, a complex assembly of 18 chains built as a hexamer of heterotrimers. Ini...

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Detalles Bibliográficos
Autores principales: Gaboriaud, Christine, Ling, Wai Li, Thielens, Nicole M., Bally, Isabelle, Rossi, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222235/
https://www.ncbi.nlm.nih.gov/pubmed/25414705
http://dx.doi.org/10.3389/fimmu.2014.00565

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222235/
https://www.ncbi.nlm.nih.gov/pubmed/25414705
http://dx.doi.org/10.3389/fimmu.2014.00565

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