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Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?
The classical complement pathway is initiated by the large (~800 kDa) and flexible multimeric C1 complex. Its catalytic function is triggered by the proteases hetero-tetramer C1r2s2, which is associated to the C1q sensing unit, a complex assembly of 18 chains built as a hexamer of heterotrimers. Ini...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222235/ https://www.ncbi.nlm.nih.gov/pubmed/25414705 http://dx.doi.org/10.3389/fimmu.2014.00565 |