Total synthesis of the proposed structure of astakolactin

The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.

Detalles Bibliográficos
Autores principales: Tonoi, Takayuki, Mameda, Keisuke, Fujishiro, Moe, Yoshinaga, Yutaka, Shiina, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222296/
https://www.ncbi.nlm.nih.gov/pubmed/25383112
http://dx.doi.org/10.3762/bjoc.10.252
Descripción
Sumario:The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.

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