Total synthesis of the proposed structure of astakolactin

The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.

Detalles Bibliográficos
Autores principales: Tonoi, Takayuki, Mameda, Keisuke, Fujishiro, Moe, Yoshinaga, Yutaka, Shiina, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222296/
https://www.ncbi.nlm.nih.gov/pubmed/25383112
http://dx.doi.org/10.3762/bjoc.10.252
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author Tonoi, Takayuki
Mameda, Keisuke
Fujishiro, Moe
Yoshinaga, Yutaka
Shiina, Isamu
author_facet Tonoi, Takayuki
Mameda, Keisuke
Fujishiro, Moe
Yoshinaga, Yutaka
Shiina, Isamu
author_sort Tonoi, Takayuki
collection PubMed
description The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.
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spelling pubmed-42222962014-11-07 Total synthesis of the proposed structure of astakolactin Tonoi, Takayuki Mameda, Keisuke Fujishiro, Moe Yoshinaga, Yutaka Shiina, Isamu Beilstein J Org Chem Full Research Paper The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson–Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization. Beilstein-Institut 2014-10-17 /pmc/articles/PMC4222296/ /pubmed/25383112 http://dx.doi.org/10.3762/bjoc.10.252 Text en Copyright © 2014, Tonoi et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Tonoi, Takayuki
Mameda, Keisuke
Fujishiro, Moe
Yoshinaga, Yutaka
Shiina, Isamu
Total synthesis of the proposed structure of astakolactin
title Total synthesis of the proposed structure of astakolactin
title_full Total synthesis of the proposed structure of astakolactin
title_fullStr Total synthesis of the proposed structure of astakolactin
title_full_unstemmed Total synthesis of the proposed structure of astakolactin
title_short Total synthesis of the proposed structure of astakolactin
title_sort total synthesis of the proposed structure of astakolactin
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222296/
https://www.ncbi.nlm.nih.gov/pubmed/25383112
http://dx.doi.org/10.3762/bjoc.10.252
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AT yoshinagayutaka totalsynthesisoftheproposedstructureofastakolactin
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