Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression

Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factor...

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Detalles Bibliográficos
Autores principales: Moriam, Sofia, Sobhani, Mahbub E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222332/
https://www.ncbi.nlm.nih.gov/pubmed/25512703
http://dx.doi.org/10.4137/GEG.S11016
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author Moriam, Sofia
Sobhani, Mahbub E
author_facet Moriam, Sofia
Sobhani, Mahbub E
author_sort Moriam, Sofia
collection PubMed
description Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. In this review, we try to portray how chronic stress as an epigenetic factor changes the gene regulation pattern by interrupting Dopamine signaling mechanism.
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spelling pubmed-42223322014-12-15 Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression Moriam, Sofia Sobhani, Mahbub E Genet Epigenet Review Because of the complex causal factors leading to depression, epigenetics is of considerable interest for the understanding effect of stress in depression. Dopamine is a key neurotransmitter important in many physiological functions, including motor control, mood, and the reward pathway. These factors lead many drugs to target Dopamine receptors in treating depressive disorders. In this review, we try to portray how chronic stress as an epigenetic factor changes the gene regulation pattern by interrupting Dopamine signaling mechanism. Libertas Academica 2013-02-10 /pmc/articles/PMC4222332/ /pubmed/25512703 http://dx.doi.org/10.4137/GEG.S11016 Text en © 2013 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article published under the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Review
Moriam, Sofia
Sobhani, Mahbub E
Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title_full Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title_fullStr Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title_full_unstemmed Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title_short Epigenetic Effect of Chronic Stress on Dopamine Signaling and Depression
title_sort epigenetic effect of chronic stress on dopamine signaling and depression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222332/
https://www.ncbi.nlm.nih.gov/pubmed/25512703
http://dx.doi.org/10.4137/GEG.S11016
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AT sobhanimahbube epigeneticeffectofchronicstressondopaminesignalinganddepression

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