Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries

New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converte...

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Detalles Bibliográficos
Autores principales: Nörrlinger, Markus, Ziegler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222372/
https://www.ncbi.nlm.nih.gov/pubmed/25383116
http://dx.doi.org/10.3762/bjoc.10.256
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author Nörrlinger, Markus
Ziegler, Thomas
author_facet Nörrlinger, Markus
Ziegler, Thomas
author_sort Nörrlinger, Markus
collection PubMed
description New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converted into their corresponding acids which are suitable building blocks for combinatorial glycopeptide synthesis.
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spelling pubmed-42223722014-11-07 Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries Nörrlinger, Markus Ziegler, Thomas Beilstein J Org Chem Full Research Paper New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converted into their corresponding acids which are suitable building blocks for combinatorial glycopeptide synthesis. Beilstein-Institut 2014-10-22 /pmc/articles/PMC4222372/ /pubmed/25383116 http://dx.doi.org/10.3762/bjoc.10.256 Text en Copyright © 2014, Nörrlinger and Ziegler https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Nörrlinger, Markus
Ziegler, Thomas
Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title_full Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title_fullStr Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title_full_unstemmed Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title_short Synthesis of aromatic glycoconjugates. Building blocks for the construction of combinatorial glycopeptide libraries
title_sort synthesis of aromatic glycoconjugates. building blocks for the construction of combinatorial glycopeptide libraries
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222372/
https://www.ncbi.nlm.nih.gov/pubmed/25383116
http://dx.doi.org/10.3762/bjoc.10.256
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