A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling. This protocol provides an operationally simple and rapid strategy for preparing indolo[1,2-a]quinazoline...

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Detalles Bibliográficos
Autores principales: Li, Chunpu, Zhang, Lei, Shu, Shuangjie, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222401/
https://www.ncbi.nlm.nih.gov/pubmed/25383114
http://dx.doi.org/10.3762/bjoc.10.254
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author Li, Chunpu
Zhang, Lei
Shu, Shuangjie
Liu, Hong
author_facet Li, Chunpu
Zhang, Lei
Shu, Shuangjie
Liu, Hong
author_sort Li, Chunpu
collection PubMed
description A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling. This protocol provides an operationally simple and rapid strategy for preparing indolo[1,2-a]quinazoline derivatives and displays good functional group tolerance. All the starting materials are commercial available or can be easily prepared.
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spelling pubmed-42224012014-11-07 A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline Li, Chunpu Zhang, Lei Shu, Shuangjie Liu, Hong Beilstein J Org Chem Full Research Paper A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling. This protocol provides an operationally simple and rapid strategy for preparing indolo[1,2-a]quinazoline derivatives and displays good functional group tolerance. All the starting materials are commercial available or can be easily prepared. Beilstein-Institut 2014-10-21 /pmc/articles/PMC4222401/ /pubmed/25383114 http://dx.doi.org/10.3762/bjoc.10.254 Text en Copyright © 2014, Li et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Li, Chunpu
Zhang, Lei
Shu, Shuangjie
Liu, Hong
A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title_full A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title_fullStr A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title_full_unstemmed A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title_short A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
title_sort simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222401/
https://www.ncbi.nlm.nih.gov/pubmed/25383114
http://dx.doi.org/10.3762/bjoc.10.254
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