Extracellular Vesicles in Hematological Disorders

Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell si...

Descripción completa

Detalles Bibliográficos
Autores principales: Aharon, Anat, Rebibo-Sabbah, Annie, Tzoran, Inna, Levin, Carina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2014
Materias:
Horizons in Hematological Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222421/
https://www.ncbi.nlm.nih.gov/pubmed/25386348
http://dx.doi.org/10.5041/RMMJ.10166
_version_ 1782343036889464832
author Aharon, Anat
Rebibo-Sabbah, Annie
Tzoran, Inna
Levin, Carina
author_facet Aharon, Anat
Rebibo-Sabbah, Annie
Tzoran, Inna
Levin, Carina
author_sort Aharon, Anat
collection PubMed
description Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. This paper will review the contribution of EVs in hematological disorders, including hemoglobinopathies (sickle cell disease, thalassemia), paroxysmal nocturnal hemoglobinuria, and hematological malignancies (lymphomas, myelomas, and acute and chronic leukemias).
format Online
Article
Text
id pubmed-4222421
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Rambam Health Care Campus
record_format MEDLINE/PubMed
spelling pubmed-42224212014-11-10 Extracellular Vesicles in Hematological Disorders Aharon, Anat Rebibo-Sabbah, Annie Tzoran, Inna Levin, Carina Rambam Maimonides Med J Horizons in Hematological Research Extracellular vesicles (EVs), comprised of exosomes, microparticles, apoptotic bodies, and other microvesicles, are shed from a variety of cells upon cell activation or apoptosis. EVs promote clot formation, mediate pro-inflammatory processes, transfer proteins and miRNA to cells, and induce cell signaling that regulates cell differentiation, proliferation, migration, invasion, and apoptosis. This paper will review the contribution of EVs in hematological disorders, including hemoglobinopathies (sickle cell disease, thalassemia), paroxysmal nocturnal hemoglobinuria, and hematological malignancies (lymphomas, myelomas, and acute and chronic leukemias). Rambam Health Care Campus 2014-10-29 /pmc/articles/PMC4222421/ /pubmed/25386348 http://dx.doi.org/10.5041/RMMJ.10166 Text en Copyright: © 2014 Aharon, et al. This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Horizons in Hematological Research
Aharon, Anat
Rebibo-Sabbah, Annie
Tzoran, Inna
Levin, Carina
Extracellular Vesicles in Hematological Disorders
title Extracellular Vesicles in Hematological Disorders
title_full Extracellular Vesicles in Hematological Disorders
title_fullStr Extracellular Vesicles in Hematological Disorders
title_full_unstemmed Extracellular Vesicles in Hematological Disorders
title_short Extracellular Vesicles in Hematological Disorders
title_sort extracellular vesicles in hematological disorders
topic Horizons in Hematological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222421/
https://www.ncbi.nlm.nih.gov/pubmed/25386348
http://dx.doi.org/10.5041/RMMJ.10166
work_keys_str_mv AT aharonanat extracellularvesiclesinhematologicaldisorders
AT rebibosabbahannie extracellularvesiclesinhematologicaldisorders
AT tzoraninna extracellularvesiclesinhematologicaldisorders
AT levincarina extracellularvesiclesinhematologicaldisorders

Ejemplares similares