AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation

BACKGROUND: The CARMA1-BCL10-MALT1 (CBM) complex bridges T cell receptor (TCR) signaling to the canonical IκB kinase (IKK)/NF-κB pathway. The CBM complex constitutes a signaling cluster of more than 1 Mio Dalton. Little is known about factors that facilitate the rapid assembly and maintenance of thi...

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Detalles Bibliográficos
Autores principales: Schimmack, Gisela, Eitelhuber, Andrea C, Vincendeau, Michelle, Demski, Katrin, Shinohara, Hisaaki, Kurosaki, Tomohiro, Krappmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222456/
https://www.ncbi.nlm.nih.gov/pubmed/25245034
http://dx.doi.org/10.1186/s12964-014-0049-7

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