Lipid droplet binding thalidomide analogs activate endoplasmic reticulum stress and suppress hepatocellular carcinoma in a chemically induced transgenic mouse model

BACKGROUND: Hepatocellular carcinoma (HCC) is the most frequent and aggressive primary tumor of the liver and it has limited treatment options. RESULTS: In this study, we report the in vitro and in vivo effects of two novel amino-trifluoro-phtalimide analogs, Ac-915 and Ac-2010. Both compounds bind...

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Detalles Bibliográficos
Autores principales: Nagy, Lajos I, Molnár, Eszter, Kanizsai, Iván, Madácsi, Ramóna, Ózsvári, Béla, Fehér, Liliána Z, Fábián, Gabriella, Marton, Annamária, Vizler, Csaba, Ayaydin, Ferhan, Kitajka, Klára, Hackler, László, Mátés, Lajos, Deák, Ferenc, Kiss, Ibolya, Puskás, László G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222488/
https://www.ncbi.nlm.nih.gov/pubmed/24268070
http://dx.doi.org/10.1186/1476-511X-12-175

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