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Protein Engineering of the N-Terminus of NEMO: Structure Stabilization and Rescue of IKKβ Binding
[Image: see text] NEMO is a scaffolding protein that, together with the catalytic subunits IKKα and IKKβ, plays an essential role in the formation of the IKK complex and in the activation of the canonical NF-κB pathway. Rational drug design targeting the IKK-binding site on NEMO would benefit from s...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222529/ https://www.ncbi.nlm.nih.gov/pubmed/25286246 http://dx.doi.org/10.1021/bi500861x |