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Oxidation-Induced Conformational Changes in Calcineurin Determined by Covalent Labeling and Tandem Mass Spectrometry
[Image: see text] The Ca(2+)/calmodulin activated phosphatase, calcineurin, is inactivated by H(2)O(2) or superoxide-induced oxidation, both in vivo and in vitro. However, the potential for global and/or local conformation changes occurring within calcineurin as a function of oxidative modification,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222536/ https://www.ncbi.nlm.nih.gov/pubmed/25286016 http://dx.doi.org/10.1021/bi5009744 |